Federal Capture Intelligence

Top HHS biological product (except diagnostic) manufacturing contractors (NAICS 325414)

Contract actions: October 1, 2021 – October 23, 2026 Updated October 24, 2026 Department of Health and Human Services agency guide NAICS 325414 · Biological Product (except Diagnostic) Manufacturing
Latest 12 months
$348.7M
Net obligations · Up $468.7M vs. -$120.0M preceding
Prime contractors
42
With positive obligations in the latest 12 months

Research the HHS federal contracting market for biological product (except diagnostic) manufacturing under NAICS 325414. Compare top federal contractors and market share, reported contract obligations and spending trends, funding-office attribution, recent award activity, contract types, competition, and procurement methods, and potential recompete research leads.

Contract obligation trends for Biological Product (except Diagnostic) Manufacturing at the Department of Health and Human Services

Federal records show $1.7B in net obligations across 1,954 awards in Biological Product (except Diagnostic) Manufacturing at the Department of Health and Human Services from Oct 1, 2021 through Oct 23, 2026. This market accounts for 1.1% of $150.2B in agency-wide net prime contract obligations over the period shown. Latest 12-month net obligations moved from $120.0M in net deobligations to $348.7M in net obligations. 3 prime contractors accounted for at least 80% of positive obligations in that latest period.

Fiscal-year activity

FY27 is year-to-date through Oct 23, 2026; earlier years show complete fiscal-year totals.

FY27 year-to-date: $248K versus $0 through the same date in FY26 (Not comparable).
Net obligations · complete fiscal yearNet obligations · FY27 YTDContract actions
View fiscal-year data table
Fiscal yearNet obligationsContract actionsCoverage
FY2022$386.9M805Complete
FY2023$199.4M622Complete
FY2024$911.6M571Complete
FY2025−$120.0M319Complete
FY2026$348.5M179Complete

Market at a glance

All reported prime contract awards
All-period net obligations
$1.7B
1,954 awards · 348 prime contractors
Latest 12-month movement
Not comparable
$348.7M vs. −$120.0M
Leading eight prime share
99.2%
Share held by the eight leading prime contractors in the latest 12 months
View agency share, denominators, and set-aside reporting
Agency context
1.1% of $150.2B in agency-wide net obligations.
Set-aside share when reported
7.6% of 1,757 awards with reported set-aside status.
Set-aside reporting
133 set aside · 1,624 no set-aside · 197 not reported

What changed in the last 12 months?

Oct 24, 2025–Oct 23, 2026, compared with Oct 24, 2024–Oct 23, 2025.

Competitive shifts

SANOFI VACCINES US INC. lost the most market share
25.4%→3.4%−22.0 percentage points
The contractor now ranks #4 by positive obligations, based on 3 reported actions.
SEQIRUS INC had the largest increase in reported obligations
$7.8M→$53.6M+$45.9M
The contractor now ranks #2 by positive obligations and accounts for 15.3% of positive obligations, based on 17 reported actions.
MILTENYI BIOTEC, INC. climbed the most in the contractor rankings
#53→#5Up 48 places
The contractor accounts for 0.79% of positive obligations across 6 reported actions.

Award activity

Market structure

Top-five contractor share increased
91.5%→98.8%+7.3 percentage points
Contractors outside the top five now account for 1.2% of positive obligations.
How these findings are calculated

Findings are selected from matched-period changes in obligations, share, rank, funding offices, concentration, reported set-asides, material award actions, and agency-peer outliers. Related signals are combined, and only material evidence-backed changes are shown. Review the full methodology.

Federal contract obligations by funding office

See how positive obligations were attributed across funding offices in the 12 months ending Oct 23, 2026.

72.1% of positive obligations were attributed to OFC ASST SEC FOR PREPARENESS RES. That represents $251.6M, up $332.4M from the preceding 12 months.

Latest 12-month share of positive obligations; the gray segment represents all other reported offices.

  1. OFC ASST SEC FOR PREPARENESS RES72.1% · $251.6M · up $332.4M
  2. ASPR/ORM-SNS15.1% · $52.8M · down $3.0M
  3. BARDA - ASPR / DAAPPO / BARDA DCMA10.9% · $37.9M · up $80.7M
  4. NATIONAL INSTITUTES OF HEALTH OLAO0.63% · $2.2M · up $2.2M
  5. NATIONAL INSTITUTES OF HEALTH - CC0.46% · $1.6M · up $621K
  6. All other reported offices0.76% of positive obligations
View reported office rankings, comparisons, and evidence

USAspending assigns each award to a funding office. That office may differ from the requiring activity, program office, contracting office, individual buyer, or actual customer.

  1. Reported funding office

    OFC ASST SEC FOR PREPARENESS RES

    #1New to the positive-obligation ranking

    Latest 12 months

    $251.6M

    72.1% of positive obligations

    Versus preceding 12 months

    +$332.4M

    2 active prime contractors · 6 awards

    View office comparison and evidence

    Reported obligations moved from $80.8M in net deobligations to $251.6M in net obligations. The office’s share of positive obligations moved from 0% to 72.1%, a change of +72.1 percentage points.

    The latest period contains 9 actions across 6 awards. The preceding period contained 5 active prime contractors and 6 awards.

    Leading award-level changes

  2. Reported funding office

    ASPR/ORM-SNS

    #2Down 1 from #1

    Latest 12 months

    $52.8M

    15.1% of positive obligations

    Versus preceding 12 months

    −$3.0M

    1 active prime contractor · 1 award

    View office comparison and evidence

    Reported obligations decreased 5.3% from $55.7M to $52.8M. The office’s share of positive obligations moved from 82.1% to 15.1%, a change of −67.0 percentage points.

    The latest period contains 1 action across 1 award. The preceding period contained 1 active prime contractor and 1 award.

  3. Reported funding office

    BARDA - ASPR / DAAPPO / BARDA DCMA

    #3New to the positive-obligation ranking

    Latest 12 months

    $37.9M

    10.9% of positive obligations

    Versus preceding 12 months

    +$80.7M

    7 active prime contractors · 25 awards

    View office comparison and evidence

    Reported obligations moved from $42.8M in net deobligations to $37.9M in net obligations. The office’s share of positive obligations moved from 0% to 10.9%, a change of +10.9 percentage points.

    The latest period contains 35 actions across 25 awards and 3 newly active prime contractors. The preceding period contained 10 active prime contractors and 31 awards.

  4. Reported funding office

    NATIONAL INSTITUTES OF HEALTH OLAO

    #4New to the positive-obligation ranking

    Latest 12 months

    $2.2M

    0.63% of positive obligations

    Versus preceding 12 months

    +$2.2M

    5 active prime contractors · 5 awards

    View office comparison and evidence

    Reported obligations moved from $35K in net deobligations to $2.2M in net obligations. The office’s share of positive obligations moved from 0% to 0.63%, a change of +0.6 percentage points.

    The latest period contains 7 actions across 5 awards and 5 newly active prime contractors. The preceding period contained 2 active prime contractors and 3 awards.

  5. Reported funding office

    NATIONAL INSTITUTES OF HEALTH - CC

    #5Rank unchanged

    Latest 12 months

    $1.6M

    0.46% of positive obligations

    Versus preceding 12 months

    +$621K

    18 active prime contractors · 21 awards

    View office comparison and evidence

    Reported obligations increased 62.2% from $999K to $1.6M. The office’s share of positive obligations moved from 1.5% to 0.46%, a change of −1.0 percentage points.

    The latest period contains 22 actions across 21 awards and 10 newly active prime contractors. The preceding period contained 25 active prime contractors and 37 awards.

  6. Reported funding office

    FDA OFFICE OF ACQ GRANT SVCS

    #6Up 4 from #10

    Latest 12 months

    $537K

    0.15% of positive obligations

    Versus preceding 12 months

    +$149K

    8 active prime contractors · 10 awards

    View office comparison and evidence

    Reported obligations increased 38.3% from $388K to $537K. The office’s share of positive obligations moved from 0.57% to 0.15%, a change of −0.4 percentage points.

    The latest period contains 10 actions across 10 awards and 7 newly active prime contractors. The preceding period contained 5 active prime contractors and 7 awards.

  7. Reported funding office

    CDC OFFICE OF ACQUISITION SERVICES

    #7Rank unchanged

    Latest 12 months

    $450K

    0.13% of positive obligations

    Versus preceding 12 months

    −$293K

    14 active prime contractors · 16 awards

    View office comparison and evidence

    Reported obligations decreased 39.4% from $742K to $450K. The office’s share of positive obligations moved from 1.1% to 0.13%, a change of −1.0 percentage points.

    The latest period contains 20 actions across 16 awards and 8 newly active prime contractors. The preceding period contained 12 active prime contractors and 12 awards.

  8. Reported funding office

    NATIONAL INSTITUTES OF HEALTH NINDS

    #8Up 10 from #18

    Latest 12 months

    $406K

    0.12% of positive obligations

    Versus preceding 12 months

    +$388K

    4 active prime contractors · 4 awards

    View office comparison and evidence

    Reported obligations increased 2157.6% from $18K to $406K. The office’s share of positive obligations moved from 0.030% to 0.12%, a change of +0.1 percentage points.

    The latest period contains 4 actions across 4 awards and 4 newly active prime contractors. The preceding period contained 1 active prime contractor and 1 award.

  9. Reported funding office

    NATIONAL INSTITUTES OF HEALTH NHGRI

    #9Down 1 from #8

    Latest 12 months

    $360K

    0.10% of positive obligations

    Versus preceding 12 months

    −$103K

    3 active prime contractors · 3 awards

    View office comparison and evidence

    Reported obligations decreased 22.3% from $464K to $360K. The office’s share of positive obligations moved from 0.68% to 0.10%, a change of −0.6 percentage points.

    The latest period contains 3 actions across 3 awards and 3 newly active prime contractors. The preceding period contained 4 active prime contractors and 8 awards.

  10. Reported funding office

    NATIONAL INSTITUTES OF HEALTH NIA

    #10Down 7 from #3

    Latest 12 months

    $279K

    0.080% of positive obligations

    Versus preceding 12 months

    −$1.3M

    3 active prime contractors · 4 awards

    View office comparison and evidence

    Reported obligations decreased 82.7% from $1.6M to $279K. The office’s share of positive obligations moved from 2.4% to 0.080%, a change of −2.3 percentage points.

    The latest period contains 4 actions across 4 awards and 2 newly active prime contractors. The preceding period contained 8 active prime contractors and 8 awards.

  11. Reported funding office

    NATIONAL INSTITUTES OF HEALTH NHLBI

    #12Down 8 from #4

    Latest 12 months

    $151K

    0.040% of positive obligations

    Versus preceding 12 months

    −$1.4M

    8 active prime contractors · 8 awards

    View office comparison and evidence

    Reported obligations decreased 90.3% from $1.6M to $151K. The office’s share of positive obligations moved from 2.3% to 0.040%, a change of −2.3 percentage points.

    The latest period contains 8 actions across 8 awards and 3 newly active prime contractors. The preceding period contained 20 active prime contractors and 39 awards.

  12. Reported funding office

    NIH NCI

    #16Down 10 from #6

    Latest 12 months

    $29K

    0.010% of positive obligations

    Versus preceding 12 months

    −$882K

    8 active prime contractors · 8 awards

    View office comparison and evidence

    Reported obligations decreased 96.8% from $912K to $29K. The office’s share of positive obligations moved from 1.3% to 0.010%, a change of −1.3 percentage points.

    The latest period contains 10 actions across 8 awards and 7 newly active prime contractors. The preceding period contained 8 active prime contractors and 14 awards.

  13. Reported funding office

    INDUSTRIAL BASED MANUFACTURING AND SUPPLY CHAIN (IBMSC)

    No positive-obligation rank

    Latest 12 months

    $0

    0% of positive obligations

    Versus preceding 12 months

    +$60.0M

    1 active prime contractor · 1 award

    View office comparison and evidence

    Reported obligations moved from $60.0M in net deobligations to $0 in net obligations. The office’s share of positive obligations moved from 0% to 0%, a change of 0.0 percentage points.

    The latest period contains 1 action across 1 award. The preceding period contained 1 active prime contractor and 3 awards.

  14. Reported funding office

    ASPR BARDA DIV CONTRACTS MGMT & ACQ

    No positive-obligation rank

    Latest 12 months

    $0

    0% of positive obligations

    Versus preceding 12 months

    +$4.2M

    0 active prime contractors · 0 awards

    View office comparison and evidence

    Reported obligations moved from $4.2M in net deobligations to $0 in net obligations. The office’s share of positive obligations moved from 0% to 0%, a change of 0.0 percentage points.

    The latest period contains 0 actions across 0 awards. The preceding period contained 2 active prime contractors and 2 awards.

  15. Reported funding office

    NATIONAL INSTITUTES OF HEALTH NIAID

    No positive-obligation rank

    Latest 12 months

    −$60K

    0% of positive obligations

    Versus preceding 12 months

    −$4.3M

    24 active prime contractors · 28 awards

    View office comparison and evidence

    Reported obligations moved from $4.2M in net obligations to $60K in net deobligations. The office’s share of positive obligations moved from 6.2% to 0%, a change of −6.2 percentage points.

    The latest period contains 29 actions across 28 awards and 13 newly active prime contractors. The preceding period contained 28 active prime contractors and 51 awards.

    Leading award-level changes

Contract types, competition, and procurement methods

From Oct 24, 2025 through Oct 23, 2026, 59 awards had positive obligations totaling $366.0M. Negotiated Proposal/Quote was the leading reported procedure, accounting for 78.4% of positive obligations. Awards with a reported parent IDV accounted for 77.4%.

Leading award type
77.4%
Delivery Order
Leading reported procedure
78.4%
Negotiated Proposal/Quote
Reported parent IDV
77.4%
of positive obligations had a reported parent IDV
Median reported offers
1
45 of 59 awards reported offers

Buying method changes

Compared with Oct 24, 2024–Oct 23, 2025. Based on 59 current awards and 180 preceding awards with positive net obligations.

Delivery-order obligation share
77.4%
Up from 8.7% in the preceding period
Median positive award obligations
$56K
Up from $23K in the preceding period
Reported full-and-open obligation share
78.4%
Up from 62.2% in the preceding period
How to read these changes

Directional color and the Up or Down labels show historical movement only. Green does not mean favorable and red does not mean unfavorable; neither predicts a future procurement method.

Same-NAICS comparison

Compared with the NAICS 325414 peer median, parent-IDV obligation share is 22.1 percentage points lower, reported full-and-open obligation share is 51.3 percentage points higher, delivery-order obligation share is 22.1 percentage points lower, and median positive award obligations are 69.5% lower.

MeasureThis marketPeer medianDifference
Parent-IDV obligation share77.4%99.5%-22.1 pts
Reported full-and-open obligation share78.4%27.1%+51.3 pts
Delivery-order obligation share77.4%99.5%-22.1 pts
Median positive award obligations$56K$183K-69.5%
Peer cohort and comparison limits

The peer median gives each of the 3 eligible agency markets equal weight. The included agency markets are:

Agency mission, scale, and acquisition context can differ. Peer position does not establish market attractiveness or predict a future procurement method.

View buying-method details and data coverage

Award types

Reported valueAwardsPositive obligationsShare
Delivery Order(C)14$283.1M77.4%
Definitive Contract(D)5$79.9M21.8%
Purchase Order(B)40$2.9M0.80%

Reported parent-award types

Reported valueAwardsPositive obligationsShare
IDC(B)14$283.1M77.4%
Not reported45$82.9M22.6%

Single- or multiple-award parent structure

Reported valueAwardsPositive obligationsShare
Single Award(S)14$283.1M77.4%
Not reported45$82.9M22.6%

Solicitation procedures

Reported valueAwardsPositive obligationsShare
Negotiated Proposal/Quote(NP)5$286.9M78.4%
Np(NEGOTIATED PROPOSAL/QUOTE)3$45.4M12.4%
Only One Source(SSS)7$27.3M7.5%
Simplified Acquisition(SP1)17$3.6M0.99%
Sp1(SIMPLIFIED ACQUISITION)20$2.1M0.58%
Sss(ONLY ONE SOURCE)7$632K0.17%

Extent competed

Reported valueAwardsPositive obligationsShare
Full and Open Competition(A)5$286.9M78.4%
A(FULL AND OPEN COMPETITION)3$45.4M12.4%
Not Competed(C)7$27.3M7.5%
Not Competed Under SAP(G)13$3.3M0.90%
G(NOT COMPETED UNDER SAP)9$1.7M0.48%
C(NOT COMPETED)7$632K0.17%
Other reported values15$717K0.20%

Fair-opportunity and limited-source reporting

Reported valueAwardsPositive obligationsShare
Not reported59$366.0M100.0%

Other-than-full-and-open reasons

Reported valueAwardsPositive obligationsShare
Only One Source-Other (FAR 6.302-1 Other)(ONE)14$28.0M7.6%
SAP Non-Competition (FAR 13)(SP2)21$5.0M1.4%
Less Than or Equal to the Micro-Purchase Threshold(MPT)1$7580%
Not reported23$333.0M91.0%

Contract pricing types

Reported valueAwardsPositive obligationsShare
Cost Plus Fixed Fee(U)2$251.6M68.8%
Firm Fixed Price(J)27$66.2M18.1%
J(FIRM FIXED PRICE)30$48.1M13.2%

Product or Service Codes

Reported valueAwardsPositive obligationsShare
Health R&d Services; Health Care - Other; Applied Research(AN42)1$225.0M61.5%
Drugs and Biologicals(6505)25$56.7M15.5%
Medical and Surgical Instruments, Equipment, and Supplies(6515)1$52.8M14.4%
Medical- Other(Q999)1$26.6M7.3%
Laboratory Equipment and Supplies(6640)14$2.6M0.70%
in Vitro Diagnostic Substances, Reagents, Test Kits and Sets(6550)10$1.5M0.40%
Other reported values7$844K0.23%

Awarding subagencies

Reported valueAwardsPositive obligationsShare
Office of Assistant Secretary for Preparedness and Response(7505)9$358.9M98.1%
National Institutes of Health(7529)38$6.0M1.6%
Centers for Disease Control and Prevention(7523)5$555K0.15%
Food and Drug Administration(7524)6$537K0.15%
Indian Health Service(7527)1$35K0.010%

Awarding offices

Reported valueAwardsPositive obligationsShare
Barda - Aspr / Daappo / Barda Dcma(75A501)8$306.1M83.6%
Aspr/Orm-Sns(75A503)1$52.8M14.4%
National Institutes of Health Olao(75N980)33$5.0M1.4%
National Institutes of Health - Cc(75N900)2$830K0.23%
Cdc Office of Acquisition Services(75D301)5$555K0.15%
Fda Office of Acq Grant Svcs(75F401)6$537K0.15%
Other reported values4$163K0.045%

Reported parent IDVs

Reported valueAwardsPositive obligationsShare
75A50123D00003(7505)1$225.0M61.5%
75A50122D00004(7505)6$54.5M14.9%
75N90023D00015(7529)3$3.0M0.82%
75N90023D00008(7529)1$330K0.090%
75F40125D00013(7524)2$160K0.040%
75N90024D00008(7529)1$127K0.030%
Not reported45$82.9M22.6%

Offers, award size, and timing

Median reported offers
1 median
45 reported · 14 not reported
Positive award obligations
$56K median
$27K–$288K middle 50%
Reported performance period
364 days (~12 months) median
59 reported · 0 not reported

Calculations group latest-period actions by award, retain awards with positive net obligations for share denominators, and use each award's latest reported USAspending procurement fields as of Oct 23, 2026. Blank competition, pricing, PSC, or parent-IDV values remain not reported; they are not inferred. Offer counts must be positive and below the FPDS 999 placeholder. Awarding organizations can differ from the funding agency that defines this page.

Top federal contractors

Latest 12-month market share, concentration, and complete prime contractor rankings across the period shown.

Prime contractor concentration
3 of 42prime contractors account for at least 80% of positive obligations in the last 12 months
Largest prime contractor
64.2%of positive obligations in the last 12 months
Leading four prime contractors
98.1%of positive obligations in the last 12 months
Leading eight prime contractors
99.2%of positive obligations in the last 12 months

Based on $350.2M in positive obligations during the 12 months ending Oct 23, 2026. Individual shares and movement appear in the searchable rankings below. Movement compares with Oct 24, 2024–Oct 23, 2025.

Last 12mo obligation volume: Highest positive obligations first; net deobligations follow by magnitude; contractors with no activity in the last 12 months follow by all-period obligations. Ranks use the complete contractor list and remain fixed when search narrows the results.

15 leading contractors
  1. #1

    Last 12mo obligations

    $225.0M

    64.2%

    Dollar movement

    +$310.7M

    vs. prior 12 months

    Last 12mo awards

    9 awards

    19 actions

    Historical and award details for ADVANCED TECHNOLOGY INTERNATIONAL
    Obligations: prior → latest
    −$85.7M → $225.0M
    Not comparable
    Share: prior → latest
    0% → 64.2%
    +64.2 percentage points
    All-period obligations
    $911.5M
    48.8% of all-period positive obligations · 9 awards
    Recorded activity
    Since Dec 12, 2023
    through Aug 19, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside00
    Not reported98
    Reported small business00
    All-period set-aside types

    None reported.

  2. #2

    Last 12mo obligations

    $53.6M

    15.3%

    Dollar movement

    +$45.9M

    vs. prior 12 months

    Last 12mo awards

    12 awards

    17 actions

    Historical and award details for SEQIRUS INC
    Obligations: prior → latest
    $7.8M → $53.6M
    +591.9%
    Share: prior → latest
    7.6% → 15.3%
    +7.7 percentage points
    All-period obligations
    $133.3M
    7.1% of all-period positive obligations · 33 awards
    Recorded activity
    Since Feb 22, 2022
    through Oct 22, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside00
    Not reported128
    Reported small business00
    All-period set-aside types

    None reported.

  3. #3

    Last 12mo obligations

    $52.8M

    15.1%

    Dollar movement

    −$3.0M

    vs. prior 12 months

    Last 12mo awards

    1 award

    1 action

    Historical and award details for EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC.
    Obligations: prior → latest
    $55.7M → $52.8M
    −5.3%
    Share: prior → latest
    55.0% → 15.1%
    −39.9 percentage points
    All-period obligations
    $328.4M
    17.6% of all-period positive obligations · 1 award
    Recorded activity
    Since Oct 25, 2021
    through Jun 26, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside11
    Not reported00
    Reported small business00
    All-period set-aside types

    None reported.

  4. #4

    Last 12mo obligations

    $12.0M

    3.4%

    Dollar movement

    −$13.7M

    vs. prior 12 months

    Last 12mo awards

    2 awards

    3 actions

    Historical and award details for SANOFI VACCINES US INC.
    Obligations: prior → latest
    $25.8M → $12.0M
    −53.3%
    Share: prior → latest
    25.4% → 3.4%
    −22.0 percentage points
    All-period obligations
    $39.6M
    2.1% of all-period positive obligations · 46 awards
    Recorded activity
    Since Oct 27, 2021
    through Apr 8, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside22
    Not reported05
    Reported small business00
    All-period set-aside types

    None reported.

  5. #5

    Last 12mo obligations

    $2.8M

    0.79%

    Dollar movement

    +$2.7M

    vs. prior 12 months

    Last 12mo awards

    4 awards

    6 actions

    Historical and award details for MILTENYI BIOTEC, INC.
    Obligations: prior → latest
    $21K → $2.8M
    +13079.5%
    Share: prior → latest
    0.020% → 0.79%
    +0.8 percentage points
    All-period obligations
    $3.5M
    0.19% of all-period positive obligations · 6 awards
    Recorded activity
    Since Jun 29, 2022
    through Oct 15, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside01
    Not reported40
    Reported small business00
    All-period set-aside types

    None reported.

  6. #6

    Last 12mo obligations

    $522K

    0.15%

    Dollar movement

    −$1.5M

    vs. prior 12 months

    Last 12mo awards

    1 award

    1 action

    Historical and award details for SOMALOGIC OPERATING CO., INC
    Obligations: prior → latest
    $2.1M → $522K
    −74.8%
    Share: prior → latest
    2.0% → 0.15%
    −1.9 percentage points
    All-period obligations
    $4.1M
    0.22% of all-period positive obligations · 13 awards
    Recorded activity
    Since Jan 28, 2022
    through May 18, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside12
    Not reported00
    Reported small business11
    All-period set-aside types

    None reported.

  7. #7

    Last 12mo obligations

    $347K

    0.10%

    Dollar movement

    +$347K

    vs. prior 12 months

    Last 12mo awards

    2 awards

    2 actions

    Historical and award details for PACIFIC BIOSCIENCES OF CALIFORNIA, INC
    Obligations: prior → latest
    $0 → $347K
    Not comparable
    Share: prior → latest
    0% → 0.10%
    +0.1 percentage points
    All-period obligations
    $656K
    0.040% of all-period positive obligations · 18 awards
    Recorded activity
    Since Nov 5, 2021
    through Jul 7, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside20
    Not reported00
    Reported small business20
    All-period set-aside types
    • 2 · Total small business
  8. #8

    Last 12mo obligations

    $330K

    0.090%

    Dollar movement

    +$330K

    vs. prior 12 months

    Last 12mo awards

    1 award

    2 actions

    Historical and award details for HOLOGIC SALES AND SERVICE, LLC
    Obligations: prior → latest
    $0 → $330K
    Not comparable
    Share: prior → latest
    0% → 0.090%
    +0.1 percentage points
    All-period obligations
    $566K
    0.030% of all-period positive obligations · 2 awards
    Recorded activity
    Since Dec 7, 2022
    through Mar 2, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside00
    Not reported10
    Reported small business00
    All-period set-aside types

    None reported.

  9. #9

    Last 12mo obligations

    $323K

    0.090%

    Dollar movement

    +$27K

    vs. prior 12 months

    Last 12mo awards

    3 awards

    3 actions

    Historical and award details for LAMPIRE BIOLOGICAL LABS INC
    Obligations: prior → latest
    $296K → $323K
    +9.1%
    Share: prior → latest
    0.29% → 0.090%
    −0.2 percentage points
    All-period obligations
    $1.3M
    0.070% of all-period positive obligations · 6 awards
    Recorded activity
    Since Nov 30, 2021
    through Sep 28, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside31
    Not reported00
    Reported small business21
    All-period set-aside types

    None reported.

  10. #10

    Last 12mo obligations

    $250K

    0.070%

    Dollar movement

    $0

    no change vs. prior 12 months

    Last 12mo awards

    1 award

    2 actions

    Historical and award details for UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Obligations: prior → latest
    $250K → $250K
    +0.0%
    Share: prior → latest
    0.25% → 0.070%
    −0.2 percentage points
    All-period obligations
    $1.2M
    0.070% of all-period positive obligations · 1 award
    Recorded activity
    Since Jun 28, 2022
    through Jul 8, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside11
    Not reported00
    Reported small business00
    All-period set-aside types

    None reported.

  11. #11

    Last 12mo obligations

    $249K

    0.070%

    Dollar movement

    −$1.3M

    vs. prior 12 months

    Last 12mo awards

    1 award

    1 action

    Historical and award details for JACKSON LABORATORY
    Obligations: prior → latest
    $1.5M → $249K
    −83.7%
    Share: prior → latest
    1.5% → 0.070%
    −1.4 percentage points
    All-period obligations
    $3.2M
    0.17% of all-period positive obligations · 5 awards
    Recorded activity
    Since Aug 31, 2022
    through Jul 1, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside11
    Not reported00
    Reported small business00
    All-period set-aside types

    None reported.

  12. #12

    Last 12mo obligations

    $230K

    0.070%

    Dollar movement

    +$133K

    vs. prior 12 months

    Last 12mo awards

    6 awards

    6 actions

    Historical and award details for BIO-RAD LABORATORIES, INC.
    Obligations: prior → latest
    $97K → $230K
    +136.3%
    Share: prior → latest
    0.10% → 0.070%
    0.0 percentage points
    All-period obligations
    $992K
    0.050% of all-period positive obligations · 36 awards
    Recorded activity
    Since Jan 25, 2022
    through Sep 22, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside63
    Not reported00
    Reported small business00
    All-period set-aside types

    None reported.

  13. #13

    Last 12mo obligations

    $207K

    0.060%

    Dollar movement

    +$148K

    vs. prior 12 months

    Last 12mo awards

    1 award

    1 action

    Historical and award details for OLINK PROTEOMICS INC
    Obligations: prior → latest
    $59K → $207K
    +252.2%
    Share: prior → latest
    0.060% → 0.060%
    0.0 percentage points
    All-period obligations
    $552K
    0.030% of all-period positive obligations · 7 awards
    Recorded activity
    Since Sep 13, 2023
    through Jun 1, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside13
    Not reported00
    Reported small business02
    All-period set-aside types

    None reported.

  14. #14

    Last 12mo obligations

    $175K

    0.050%

    Dollar movement

    +$175K

    vs. prior 12 months

    Last 12mo awards

    1 award

    1 action

    Historical and award details for REPLIGEN CORPORATION
    Obligations: prior → latest
    $0 → $175K
    Not comparable
    Share: prior → latest
    0% → 0.050%
    +0.1 percentage points
    All-period obligations
    $175K
    0.010% of all-period positive obligations · 1 award
    Recorded activity
    Since May 28, 2026
    through May 28, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside10
    Not reported00
    Reported small business10
    All-period set-aside types

    None reported.

  15. #15

    Last 12mo obligations

    $160K

    0.050%

    Dollar movement

    −$177K

    vs. prior 12 months

    Last 12mo awards

    2 awards

    2 actions

    Historical and award details for FUJIFILM BIOSCIENCES INC.
    Obligations: prior → latest
    $337K → $160K
    −52.4%
    Share: prior → latest
    0.33% → 0.050%
    −0.3 percentage points
    All-period obligations
    $561K
    0.030% of all-period positive obligations · 6 awards
    Recorded activity
    Since Aug 17, 2022
    through Sep 23, 2026

    Award reporting

    Latest and prior 12-month award reporting
    Reported award evidenceLatestPrior
    Reported set-aside00
    Reported no set-aside01
    Not reported21
    Reported small business00
    All-period set-aside types

    None reported.

Potential federal contract recompetes

Investigate potential recompetes surfaced by near-term end dates, award value, and recent contract changes.

ADVANCED TECHNOLOGY INTERNATIONAL

OT: THE PURPOSE OF THIS MODIFICATION IS TO ADMINISTRATIVELY UPDATE ATTACHMENT 1, SECTION 7. TASK ORDER POINTS OF CONTACT

$248.5M is obligated on an award with a reported potential end date of September 29, 2027.

Performance period

68.9%

As of Oct 23, 2026Potential end Sep 29, 2027

Current award value as a share of potential value

100.0%

$248.5M current$248.5M potential
Supporting data

Reported performance starts Sep 27, 2024.

No later potential end date is reported; current and potential end dates are both Sep 29, 2027.

$248.5M is obligated against $248.5M in current reported award value (100.0%).

Obligations are compared with current reported award value, not treated as a contract ceiling.

PIID 75A50424F64001

CANGENE CORPORATION

ADD FUNDING.

$510.9M is obligated on an award with a reported potential end date of December 31, 2027.

Performance period

94.5%

As of Oct 23, 2026Potential end Dec 31, 2027

Current award value as a share of potential value

86.0%

$510.9M current$594.2M potential
Supporting data

Reported performance starts May 30, 2006.

No later potential end date is reported; current and potential end dates are both Dec 31, 2027.

$510.9M is obligated against $510.9M in current reported award value (100.0%).

Obligations are compared with current reported award value, not treated as a contract ceiling.

PIID HHSO100200600017C

SANOFI VACCINES US INC.

THE PURPOSE OF THIS MODIFICATION: 1) TO REPLACE KRISTIN KELLY WITH SARAH HUMPHREY AS PRINCIPAL INVESTIGATOR ON THE CONTRACT (SEE FOLLOW-ON PAGE). 2) ALL OTHER TERMS AND CONDITIONS REMAIN THE SAME AND IN FULL FORCE AND EFFECT.

$53.2M is obligated on an award with a reported potential end date of January 31, 2028.

Performance period

57.5%

As of Oct 23, 2026Potential end Jan 31, 2028

Current award value as a share of potential value

66.6%

$53.2M current$79.8M potential
Supporting data

Reported performance starts Feb 1, 2025.

Current performance is reported through Jan 31, 2027.

$53.2M is obligated against $53.2M in current reported award value (100.0%).

Obligations are compared with current reported award value, not treated as a contract ceiling.

PIID 75A50125C00002

These are research leads, not confirmed recompetes. USAspending records through Oct 23, 2026; reported dates and values can change through later modifications.

Recent federal contract award activity

Recent contract actions with unusually large obligation changes or meaningful shifts in contractor and funding-office activity.

Base award

This action

+$42.8M

SEQIRUS INC

BARDA - ASPR / DAAPPO / BARDA DCMA

FORMULATION AND FILLING OF MF59-ADJUVANTED CELL-BASED A/HENAN/4-10CNIC/2022 (H3N8)-LIKE VACCINE AND CLINICAL TRIAL IMPLEMENTATION

Why it stands out

One action represented 12.2% of the market’s latest 12-month positive obligations.

At $42.8M, the action was large enough to materially affect the latest 12-month market picture.

Award net obligations
$42.8M
Share of 12-month positive obligations
12.2%
Supporting data
Prime contractor
#2 · 15.3% share
up 1 rank · +7.7 percentage points · $45.9M net increase; action accounted for 93.2%
Funding office
#3 · 10.9% attributed share
+10.9 percentage points · $80.7M net increase; action accounted for 53.0%
Related:Largest contractor gain
PIID 75A50126F61015
Modification

This action

+$210.0M

ADVANCED TECHNOLOGY INTERNATIONAL

OFC ASST SEC FOR PREPARENESS RES

OTA: THE PURPOSE OF THIS MODIFICATION IS TO INCREASE THE TOTAL ESTIMATED COST AND ADD FUNDING.

Why it stands out

One action equaled at least half of the market’s latest 12-month positive obligations.

The $210.0M action represented 60.0% of the market’s positive obligations over the latest 12 months.

Award net obligations
$304.0M
Share of 12-month positive obligations
60.0%
Supporting data
Prime contractor
#1 · 64.2% share
+64.2 percentage points · $310.7M net increase; action accounted for 67.6%
Funding office
#1 · 72.1% attributed share
+72.1 percentage points · $332.4M net increase; action accounted for 63.2%
Related:Unusually large action
PIID 75A50124F61002 · Mod P00009
Modification

This action

+$52.8M

EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC.

ASPR/ORM-SNS

ACAM2000, SMALLPOX (VACCINIA) VACCINE, LIVE (ACAM)

Why it stands out

This award grew while spending attributed to its office declined.

The modification added $52.8M while office-attributed obligations fell $3.0M overall.

Award net obligations
$857.6M
Share of 12-month positive obligations
15.1%
Supporting data
Prime contractor
#3 · 15.1% share
$3.0M net decline despite this positive action
Funding office
#2 · 15.1% attributed share
$3.0M net decline despite this positive action
PIID 75A50119C00071 · Mod P00015
Deobligation

This action

−$14.6M

SANOFI VACCINES US INC.

BARDA - ASPR / DAAPPO / BARDA DCMA

NO-COST SUPPLEMENTAL AGREEMENT TO INCORPORATE BY EXECUTIVE ORDER 14042 - FAR DEVIATION CLAUSE 52.223-99, ENSURING ADEQUATE COVID SAFETY PROTOCOLS FOR FEDERAL CONTRACTORS. NO OTHER CHANGES APPLY.

Why it stands out

The award contracted while office-attributed spending grew overall.

The action removed $14.6M while office-attributed spending rose $80.7M.

Award net obligations
$18.8M
Share of 12-month positive obligations
4.2%
Supporting data
Prime contractor
#4 · 3.4% share
down 2 ranks · −22.0 percentage points · $13.7M net decline; action exceeded it by $851K
Funding office
#3 · 10.9% attributed share
$80.7M net increase despite this negative action
Related:Largest share loss
PIID HHSO100201600039C · Mod P00008
Base award

This action

+$1.1M

MILTENYI BIOTEC, INC.

NATIONAL INSTITUTES OF HEALTH - CC

EXERCISING OPTION YEAR FOUR (4) POP 10/01/2026-09/30/2027

Why it stands out

The contractor climbed 48 positions in this market.

It now ranks #5 by positive obligations over the latest 12 months.

Award net obligations
$1.1M
Share of 12-month positive obligations
0.31%
Supporting data
Prime contractor
#5 · 0.79% share
up 48 ranks · +0.8 percentage points · $2.7M net increase; action accounted for 40.2%
Related:Largest rank gain
PIID 75N98027F00001
Deobligation

This action

−$638K

GLAXOSMITHKLINE, LLC

BARDA - ASPR / DAAPPO / BARDA DCMA

MODIFICATION P00012 IS TO DEOBLIGATE THE REMAINING FUNDS AND CLOSE THE ORDER.

Why it stands out

The award contracted while the contractor grew overall.

The action removed $638K while the contractor rose $880K.

Award net obligations
$4.9M
Share of 12-month positive obligations
0.18%
Supporting data
Prime contractor
0% share
$880K net increase despite this negative action
Funding office
#3 · 10.9% attributed share
$80.7M net increase despite this negative action
PIID 75A50119F33008 · Mod P00012
View recent award activity by date (10)
  1. SEQIRUS INCDeobligation · PIID HHSO10033019T
    Action−$781K
    Award net obligations$3.5M
  2. SEQIRUS INCDeobligation · PIID HHSO10033006T
    Action−$66K
    Award net obligations$2.2M
  3. SEQIRUS INCDeobligation · PIID HHSO10033017T
    Action−$4K
    Award net obligations$1.3M
  4. SEQIRUS INCDeobligation · PIID HHSO10033016T
    Action−$662
    Award net obligations$2K
  5. SEQIRUS INCDeobligation · PIID 75A50118F33025
    Action−$34
    Award net obligations$11K
  6. MILTENYI BIOTEC, INC.Base award · PIID 75N98027F00001
    Action+$1.1M
    Award net obligations$1.1M
  7. MOLECULAR INSTRUMENTS, INCDeobligation · PIID 75N98C21K00031
    Action−$414
    Award net obligations$20K
  8. SEQIRUS INCBase award · PIID 75A50126F61015
    Action+$42.8M
    Award net obligations$42.8M
  9. LAMPIRE BIOLOGICAL LABS INCBase award · PIID 75F40126P00297
    Action+$35K
    Award net obligations$35K
  10. LONZA WALKERSVILLE, INCBase award · PIID 75N98026P01800
    Action+$31K
    Award net obligations$31K

HHS biological product (except diagnostic) manufacturing market FAQs

Answers based on reported federal contract data.

Who are the top HHS biological product (except diagnostic) manufacturing contractors?

In the 12 months through October 23, 2026, ADVANCED TECHNOLOGY INTERNATIONAL, SEQIRUS INC, and EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. were the leading HHS biological product (except diagnostic) manufacturing prime contractors by positive obligations.

  1. #1

    ADVANCED TECHNOLOGY INTERNATIONAL

    $224,999,997 in positive obligations

  2. #2

    SEQIRUS INC

    $53,644,068 in positive obligations

  3. #3

    EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC.

    $52,780,490 in positive obligations

Rankings use reported USAspending award data.

How did HHS net obligations change in the biological product (except diagnostic) manufacturing market?

HHS net prime contract obligations for biological product (except diagnostic) manufacturing under NAICS 325414 changed from -$119,969,936 in the preceding 12 months to $348,702,441 in the 12 months through October 23, 2026. A percentage change is not stated because the preceding value was not positive or the latest value was negative.

Latest 12 months
$348,702,441
Net prime contract obligations
Preceding 12 months
-$119,969,936
Net prime contract obligations
Change
Not comparable
No percentage reported

Reported contract actions, not outlays or a forecast.

What recent HHS contract award activity was reported in the biological product (except diagnostic) manufacturing market?

Recent HHS contract award activity reported in the biological product (except diagnostic) manufacturing market included actions for SEQIRUS INC, ADVANCED TECHNOLOGY INTERNATIONAL, and EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. during the 12 months through October 23, 2026.

Action obligations are transaction-level amounts, not current award-level obligations.

Which procurement methods were reported for HHS contracts under NAICS 325414?

From October 24, 2025 through October 23, 2026, HHS reported 59 positive-obligation awards for biological product (except diagnostic) manufacturing under NAICS 325414. The leading award type was delivery order. The leading reported procedure was negotiated proposal/quote.

Positive-obligation awards
59
Leading reported procedure
Negotiated Proposal/Quote
78.4% of positive obligations
Leading award type
Delivery Order
77.4% of positive obligations
Full and open
78.4%
of positive obligations
Reported parent IDV
77.4%
of positive obligations

Percentages use positive obligations as the denominator.

Which HHS biological product (except diagnostic) manufacturing awards may warrant recompete research?

3 HHS biological product (except diagnostic) manufacturing awards may warrant recompete research based on reported potential-end dates, including awards held by ADVANCED TECHNOLOGY INTERNATIONAL, CANGENE CORPORATION, and SANOFI VACCINES US INC.

Research leads, not confirmed recompetes. Dates may change through later modifications.

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Related market research

Complete market indexes:

Same NAICS at other agencies:

Nearby NAICS at this agency:

Markets sharing leading prime records:

Leading-prime vehicle memberships:

Company memberships do not establish award-channel use.

Reported obligations include contract actions from October 1, 2021 through October 23, 2026. Set-aside and business-size fields reflect award records, not a contractor's current eligibility.

Review data methodology